| NHLBI-Emory Advanced Cardiac CT Reconstruction NCT05372627 | NOT_YET_RECRUITING | N/A | 1000 | 2031-01-30 | Jul 14, 2026 |
| A Clinical Trial Assessing the Safety and Effectiveness of the DurAVR® THV System NCT07194265 | RECRUITING | NA | 1650 | 2038-03 | Jul 14, 2026 |
| Edwards CLASP TR EFS NCT03745313 | COMPLETED | NA | 65 | 2025-05-13 | Jul 10, 2026 |
| Optimized Expansion of the Implanted Transcatheter Aortic Valve NCT07042529 | RECRUITING | NA | 1010 | 2033-07-01 | Jul 10, 2026 |
| Validation Of anatomY-specific Aortic Valve Implantation Guided by Software Using EncantoR NCT07696182 | NOT_YET_RECRUITING | NA | 150 | 2038-12-30 | Jul 10, 2026 |
| Post-Dilatation in Balloon-Expandable TAVI Prostheses NCT07477002 | ACTIVE_NOT_RECRUITING | NA | 146 | 2031-04 | Jul 10, 2026 |
| Spanish Prospective Registry of Hydra THV for Transcatheter Aortic Valve Implantation NCT07566624 | RECRUITING | N/A | 100 | 2029-02-01 | Jul 10, 2026 |
| Post-Market Clinical Follow Up Study With Navitor Valve NCT06008080 | RECRUITING | N/A | 1000 | 2032-06 | Jul 10, 2026 |
| Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis NCT07695701 | NOT_YET_RECRUITING | PHASE4 | 150 | 2030-11 | Jul 10, 2026 |
| A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. NCT06458907 | NOT_YET_RECRUITING | NA | 780 | 2032-11 | Jul 9, 2026 |
| Abbott Structural Heart Device Registry NCT06590467 | RECRUITING | N/A | 2500 | 2039-11 | Jul 9, 2026 |
| A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy NCT06979362 | RECRUITING | PHASE2 | 200 | 2028-07-25 | Jul 9, 2026 |
| Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial NCT03706833 | ACTIVE_NOT_RECRUITING | NA | 1247 | 2031-06-30 | Jul 8, 2026 |
| INTREPID: A Study of Sapablursen Evaluating the Safety and Efficacy in Participants With Polycythemia Vera (PV) NCT07429266 | RECRUITING | PHASE3 | 250 | 2031-01 | Jul 8, 2026 |
| ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve NCT05172960 | RECRUITING | NA | 1234 | 2037-01 | Jul 8, 2026 |
| Selection of Transcatheter Heart vaLve With Intermediate Sizing in Patients With Severe Aortic Stenosis Treated With Transcatheter Aortic Valve Replacement NCT07689279 | NOT_YET_RECRUITING | PHASE4 | 604 | 2033-08-01 | Jul 8, 2026 |
| A Study to Evaluate the Safety and Performance of TruGamma System for Tricuspid Replacement NCT07691307 | RECRUITING | NA | 180 | 2028-08-30 | Jul 8, 2026 |
| ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™ NCT06608823 | RECRUITING | NA | 1016 | 2036-02 | Jul 7, 2026 |
| Tricuspid Regurgitation Treatment With LAPLACE Transcatheter Tricuspid Valve Replacement System NCT07687485 | NOT_YET_RECRUITING | NA | 700 | 2038-09 | Jul 7, 2026 |
| CLASP II TR (PASCAL for TR) NCT04097145 | RECRUITING | NA | 1270 | 2031-12-31 | Jul 6, 2026 |
| Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial NCT05496998 | RECRUITING | NA | 400 | 2038-12 | Jul 6, 2026 |
| In-vitro Benchmarking of Currently Available Heart Valve Prostheses for Surgical and Percutaneous Treatment of Aortic Stenosis With Small Annulus, Followed by In-vivo Validation NCT06859255 | RECRUITING | NA | 200 | 2027-02-07 | Jul 2, 2026 |
| A Post-Market Assessment of the Safety and Performance of the TriClip™ System NCT07586995 | RECRUITING | N/A | 1000 | 2033-08 | Jul 2, 2026 |
| PERFECT - Portuguese Evolut Registry Studying the Outcomes of Medtronic Evolut™ FX+ TAVI System by Evaluating an Optimal Care Pathway for TAVI NCT07343674 | RECRUITING | N/A | 500 | 2028-04 | Jul 2, 2026 |
| Aspirin Monotherapy Versus Sequential Warfarin-Aspirin Therapy After TAVR in Patients With Pure Aortic Regurgitation NCT07677410 | NOT_YET_RECRUITING | NA | 1172 | 2030-07-01 | Jul 1, 2026 |
| CT TAVR Abdomen Study NCT05758701 | RECRUITING | PHASE4 | 164 | 2028-03-01 | Jul 1, 2026 |
| Internet-delivered Cognitive-Behavioral Therapy for Adolescents With Autism and Anxiety NCT06537128 | ACTIVE_NOT_RECRUITING | NA | 139 | 2026-09-01 | Jun 30, 2026 |
| Redo Surgery or Transcatheter Valve-in-Valve for Mitral Bioprosthetic Dysfunction (SURViV) NCT04402931 | COMPLETED | NA | 150 | 2025-08-01 | Jun 30, 2026 |
| Aspirin vs Clopidogrel After TAVR NCT05493657 | RECRUITING | NA | 270 | 2027-07-21 | Jun 30, 2026 |
| Intrepid TMVR Pivotal NCT03242642 | RECRUITING | NA | 1056 | 2036-09-30 | Jun 29, 2026 |
| ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement NCT05672836 | RECRUITING | PHASE4 | 1040 | 2029-04 | Jun 29, 2026 |
| TTVR Early Feasibility Study NCT04433065 | RECRUITING | NA | 150 | 2031-07-30 | Jun 29, 2026 |
| Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest NCT06617377 | RECRUITING | NA | 263 | 2029-09 | Jun 29, 2026 |
| The CardioClip Study NCT06241430 | RECRUITING | NA | 60 | 2030-06 | Jun 29, 2026 |
| Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study NCT05712161 | ACTIVE_NOT_RECRUITING | NA | 15 | 2033-12 | Jun 26, 2026 |
| DurAVR™ THV System: EMBARK Study NCT05182307 | ACTIVE_NOT_RECRUITING | NA | 150 | 2028-04 | Jun 26, 2026 |
| CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material NCT07276711 | RECRUITING | NA | 663 | 2028-05 | Jun 26, 2026 |
| Cardiovalve Transfemoral Mitral Valve System NCT03813524 | TERMINATED | NA | 1 | 2020-03-31 | Jun 25, 2026 |
| REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure NCT06557798 | RECRUITING | N/A | 550 | 2033-03 | Jun 25, 2026 |
| Comparison of Single vs. Dual Perclose Devices for Large-Bore Access Closure in TAVR NCT06871774 | RECRUITING | NA | 300 | 2027-06 | Jun 25, 2026 |
| This Study Will Evaluate the Safety and Potential Complications of Dual ProGlide vs Single ProGlide and Angioseal for Common Femoral Arteriotomy Closure Following Transcatheter Aortic Valve Replacement NCT06983938 | COMPLETED | NA | 92 | 2025-10-15 | Jun 25, 2026 |
| PRIMATY (MitraClip vs medical therapy for secondary MR) NCT05051033 | ACTIVE_NOT_RECRUITING | NA | 450 | 2030-11-15 | Jun 24, 2026 |
| A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation NCT04147884 | ACTIVE_NOT_RECRUITING | NA | 4 | 2026-11 | Jun 24, 2026 |
| Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI). NCT01586910 | ACTIVE_NOT_RECRUITING | NA | 1746 | 2026-11 | Jun 24, 2026 |
| PASCAL Feasibility Study NCT07301151 | RECRUITING | NA | 120 | 2027-06-30 | Jun 24, 2026 |
| Percutaneous Pulmonary Artery Denervation (PADN) for the Treatment of Pulmonary Hypertension After Transcatheter Mitral Valve Edge-to-Edge Repair (M-TEER): A Prospective Cohort Study NCT07662655 | RECRUITING | EARLY_PHASE1 | 60 | 2028-08-31 | Jun 23, 2026 |
| An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Crohn's Disease NCT03759288 | TERMINATED | PHASE2, PHASE3 | 89 | 2023-10-18 | Jun 23, 2026 |
| Early Warning of Structural Complications in Perimembranous VSD NCT07662343 | ACTIVE_NOT_RECRUITING | N/A | 11683 | 2027-07-01 | Jun 23, 2026 |
| A Clinical Study of X-Clip Mitral Valve Clip System and Steerable Guide System for Transcatheter Mitral Valve Repair of Degenerative Mitral Regurgitation NCT07660185 | NOT_YET_RECRUITING | NA | 15 | 2032-08-31 | Jun 22, 2026 |
| Safety Profile Evaluation of TICagrelor Alone Compared to a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of Transcatheter Aortic Valve Implantation (TAVI) NCT02817789 | TERMINATED | PHASE3 | 50 | 2018-05-30 | Jun 22, 2026 |
| Abbott Cephea Mitral Valve Disease Registry NCT07069673 | RECRUITING | N/A | 1000 | 2028-12 | Jun 22, 2026 |
| Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires NCT03152773 | COMPLETED | NA | 22 | 2021-12-14 | Jun 22, 2026 |
| Left Atrial and Left Ventricular Structural and Functional Evaluation by CCTA for Predicting Post-Ablation Outcomes in Patients With Atrial Fibrillation NCT07651046 | WITHDRAWN | N/A | 0 | 2028-08 | Jun 22, 2026 |
| Clinical and CPET Parameters That Predict Improvement in Functional Capacity After TAVI NCT06833762 | RECRUITING | N/A | 161 | 2026-07 | Jun 22, 2026 |
| STretch and Myocardial Characterization in Arrythmogenic Mitral Valve Prolapse-2 NCT04852731 | ACTIVE_NOT_RECRUITING | NA | 280 | 2027-11-29 | Jun 18, 2026 |
| BIVOLUTX: Bicuspid Aortic Stenosis With Evolut Platform International Experience. NCT03495050 | COMPLETED | N/A | 150 | 2020-12-17 | Jun 18, 2026 |
| NHLBI and Cook Trans-Atrial Intra-Pericardial Tricuspid Annuloplasty (TRAIPTA) Early Feasibility Study NCT06479824 | SUSPENDED | NA | 60 | 2030-09-01 | Jun 17, 2026 |
| Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation NCT03433274 | ACTIVE_NOT_RECRUITING | NA | 103 | 2028-06 | Jun 17, 2026 |
| Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PCI Trial NCT04310046 | ACTIVE_NOT_RECRUITING | NA | 986 | 2031-07 | Jun 16, 2026 |
| Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication NCT06049654 | RECRUITING | NA | 104 | 2027-11-01 | Jun 15, 2026 |
| STS/ACC TVT Registry Mitral Module NCT02245763 | RECRUITING | N/A | 4000 | 2030-12-31 | Jun 15, 2026 |
| Evaluation of the Safety and Effectiveness of CHORDS® Cerebral Protection System During TAVR: DUET Trial NCT07648693 | RECRUITING | NA | 240 | 2026-12-31 | Jun 15, 2026 |
| The ShortCut™ Continued Access Study Protocol NCT06211296 | COMPLETED | NA | 8 | 2025-05-12 | Jun 12, 2026 |
| TAVI Without Balloon Predilatation (of the Aortic Valve ) SAPIEN 3 NCT02729519 | COMPLETED | NA | 250 | 2018-08-09 | Jun 12, 2026 |
| Safety and Effectiveness Study of DragonFly-T System for Severe Tricuspid Regurgitation NCT05556460 | RECRUITING | NA | 236 | 2032-08-15 | Jun 12, 2026 |
| Evaluation and Validation of Management Strategy for Conductive Disorders After TAVR (EVATAVI) NCT05417464 | COMPLETED | NA | 250 | 2024-10-04 | Jun 12, 2026 |
| The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes NCT01047735 | ACTIVE_NOT_RECRUITING | NA | 69 | 2028-07-01 | Jun 11, 2026 |
| Transcatheter Mitral and Tricuspid Interventions: a Cardiac Magnetic Resonance Study NCT07370467 | RECRUITING | N/A | 250 | 2026-09-30 | Jun 9, 2026 |
| Portico Next Generation Approval Study NCT04011722 | ACTIVE_NOT_RECRUITING | NA | 333 | 2027-12 | Jun 9, 2026 |
| AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation NCT05035277 | COMPLETED | PHASE3 | 360 | 2026-06-05 | Jun 9, 2026 |
| Impact of Local Tissue Inflammation on Intramyocardial Conduction Pathways Post Percutaneous Valve : Evaluation by Positron Emission Tomography on Exploratory Cohort NCT05308888 | RECRUITING | PHASE2 | 100 | 2028-11-23 | Jun 9, 2026 |
| The ShortCut Post-Market Study NCT07631988 | NOT_YET_RECRUITING | N/A | 150 | 2027-09 | Jun 8, 2026 |
| A Study of Electrocardiogram and Focused Cardiac Ultrasound for Enhanced Cardiac Disease Screening NCT06891222 | ACTIVE_NOT_RECRUITING | N/A | 2705 | 2026-12 | Jun 8, 2026 |
| Artificial Intelligence Assisting Transcatheter Mitral Edge-to-Edge Repair NCT07632794 | ACTIVE_NOT_RECRUITING | N/A | 1500 | 2030-08-31 | Jun 8, 2026 |
| Cerebral Embolic Protection Device During TAVR NCT07627984 | COMPLETED | NA | 260 | 2025-04-16 | Jun 4, 2026 |
| Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO) NCT07626567 | NOT_YET_RECRUITING | N/A | 500 | 2028-02 | Jun 4, 2026 |
| Correlation and Prognostic Value of Body Composition, Cardiac Structure and Function in Patients With Different Heart Failure Subtypes NCT07619222 | NOT_YET_RECRUITING | N/A | 1000 | 2028-06-01 | Jun 3, 2026 |
| Colchicine for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement NCT04870424 | COMPLETED | PHASE3 | 120 | 2025-06-03 | Jun 3, 2026 |
| Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip NCT04729933 | ACTIVE_NOT_RECRUITING | NA | 10 | 2030-12-31 | Jun 3, 2026 |
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation NCT07623083 | NOT_YET_RECRUITING | N/A | 300 | 2034-06-05 | Jun 3, 2026 |
| Reduction of Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US) NCT07130994 | NOT_YET_RECRUITING | NA | 15 | 2032-01 | Jun 2, 2026 |
| Aortic Stenosis - Prognosis, Risk and Outcomes NCT06863883 | RECRUITING | N/A | 300 | 2031-06 | Jun 2, 2026 |
| Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) NCT06818006 | NOT_YET_RECRUITING | PHASE4 | 600 | 2030-12 | Jun 2, 2026 |
| Radial Versus Femoral Secondary Access in Patients Undergoing TAVI NCT07399392 | RECRUITING | NA | 600 | 2028-12-31 | Jun 2, 2026 |
| EFS of the DUO System for Tricuspid Regurgitation NCT05913908 | RECRUITING | NA | 15 | 2029-10 | Jun 1, 2026 |
| Localization of Anatomical Structures Involved in Nodal Tachycardias by High Density Mapping. NCT05296954 | RECRUITING | NA | 20 | 2026-12 | Jun 1, 2026 |
| Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR NCT04139616 | RECRUITING | N/A | 2000 | 2027-12-25 | Jun 1, 2026 |
| TRanscatheter Aortic-Valve Implantation Without On-site Cardiac Surgery NCT07604402 | RECRUITING | NA | 1612 | 2034-05-25 | May 29, 2026 |
| Cerebral Microembolization During Transcatheter Aortic Valve Implantation: Comparing Balloon-expandable and Self-expanding Valves NCT07614100 | NOT_YET_RECRUITING | NA | 80 | 2027-02-01 | May 29, 2026 |
| REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE NCT06777368 | RECRUITING | N/A | 225 | 2027-11 | May 28, 2026 |
| Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation NCT04818502 | ACTIVE_NOT_RECRUITING | N/A | 200 | 2028-05-31 | May 28, 2026 |
| Sapien 3 Transcatheter Aortic Valve Replacement in Young Aortic Valve Stenosis Patients From China NCT06830499 | RECRUITING | N/A | 450 | 2031-06-30 | May 27, 2026 |
| Identifying Biological Markers of Cardiovascular Events in Patients With Aortic Stenosis or TAVI NCT06713889 | RECRUITING | N/A | 125 | 2030-06 | May 27, 2026 |
| TAVI in LOW RISK in the REAL WORLD NCT07605780 | COMPLETED | N/A | 650 | 2025-08-24 | May 26, 2026 |
| Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation NCT07605715 | RECRUITING | N/A | 60 | 2027-08 | May 26, 2026 |
| Navitor Japan Study NCT07193888 | RECRUITING | N/A | 100 | 2028-08 | May 26, 2026 |
| A Multimodal Strategy to Screen for and Rule-Out Delayed High-Grade Conduction Disturbances After TAVR NCT07414485 | COMPLETED | N/A | 209 | 2026-04-23 | May 22, 2026 |
| Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes NCT03728049 | RECRUITING | NA | 944 | 2026-12 | May 22, 2026 |
| Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly NCT02972008 | RECRUITING | N/A | 542 | 2027-02 | May 22, 2026 |
| EMPagliflozin After Aortic Valve Replacement NCT06171802 | COMPLETED | PHASE4 | 206 | 2026-05-18 | May 22, 2026 |
| Diagnostic Study of Structural Heart Disease Based on Cardiac Electromechanical Signals NCT07603115 | NOT_YET_RECRUITING | N/A | 1300 | 2027-12 | May 22, 2026 |
| Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation NCT06414265 | RECRUITING | NA | 30 | 2030-02 | May 20, 2026 |
| Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter Aortic Valve Implantation (POPular ACE TAVI) NCT05774691 | COMPLETED | PHASE4 | 1000 | 2026-01-02 | May 20, 2026 |
| REPAIR-MR (MitraClip vs surgery for primary MR) NCT04198870 | ACTIVE_NOT_RECRUITING | NA | 500 | 2035-12 | May 15, 2026 |
| Evolut Low Risk (long-term follow-up) NCT02701283 | ACTIVE_NOT_RECRUITING | NA | 2223 | 2029-06 | May 7, 2026 |
| TRISCEND II (Evoque tricuspid replacement) NCT04482062 | ACTIVE_NOT_RECRUITING | NA | 864 | 2030-06-27 | Feb 27, 2026 |
| APOLLO (Tendyne TMVR) NCT04101357 | TERMINATED | PHASE1, PHASE2 | 54 | 2024-05-23 | Mar 18, 2025 |
| TRILUMINATE Pivotal (TriClip for TR) NCT03904147 | ACTIVE_NOT_RECRUITING | NA | 572 | 2029-04 | Dec 19, 2024 |
| GATE Pivotal (NaviGate tricuspid replacement) NCT05071768 | COMPLETED | NA | 31 | 2023-02-16 | Jun 27, 2024 |
| SAPIEN M3 TMVR Early Feasibility NCT05490992 | COMPLETED | NA | 2448 | 2021-12-31 | Feb 6, 2024 |
| PARTNER 3 Low Risk (5-year follow-up) NCT04728698 | WITHDRAWN | PHASE2 | 0 | 2021-09 | Sep 16, 2021 |
